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KMID : 0356919920250020381
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Korean Journal of Anesthesiology
1992 Volume.25 No. 2 p.381 ~ p.286
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The Effect of Succinylcholine on the Action Duration of Vecuronium, Nondeporlarixing Neuromuscular Blocker
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Abstract
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Sixty healthy adult patients undergoing general anesthesia for elective surgery were randomly allocated to three group(n=20), and their EMG response(twich height) of the adductor digiti mini muscle(hypothena) to TOF stimulation of ulnar nerve by
Datex
relaxograph was monitored.
The patients were received a bolus injection of vecuronium(0.1mg/kg) alone in group I, vecuronium(0.1mg/kg)after 25~50% recovery from SCh(1mg/kg)in group Ⅱ, and the mixed injection of SCh(1mg/kg)and vecuronium(0.1mg/kg) in groupⅢ.
The onset time(mean SEM) of effect of vecuronium(0.1mg/kg) in groupⅡ(2.2(0.4 min) and group Ⅲ(1.7(0.2 min) significantly was shorten when compared with a bolus injection of vecuronium alone in group(4.4(0.4min)(p<0.05).
The duration(mean(SEM) of vecuronium(0.1mg/kg), however, had no significant differences among three group. It was 33(2 min in group I, 39(3 min in groupⅡ, and 34 (2 min in group Ⅲ.
The potency of twitch height depression of vecuronium(0.1mg/kg)was increased significantly following preinjection of SCh(1mg/kg) and at the mixed injection of SCh and vecuronium
The intensity of fasciculation induced by SCh was not affected at the mixed injection of vecuronium in groupⅢ.
The peak increases in arterial pressure and heart rate on the endotracheal intubation ware attenuated significantly at the mixed injection of SCh(1mg/kg) and vecuronium(0.1mg/kg)when compared with its effect of SCh(1mg/kg)in groupⅡ(p<0.05).
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